Charlene K 1 Posted January 12, 2010 Charlene K, I am so glad Savella is working so well for you. I hope it continues long term. I tried Savella for 3 days and got the shakes because I take Zoloft as well. Have you noticed any reduction of anxiety or depression?(if you have that challenge) I would be afraid of going off my Zoloft otherwise. My new muscle relaxer seems to help. Like you, I'm hoping the effects don't wear off. Hang in there everyone. Tina I guess I must have been depressed because I do feel so much better....the pain was getting to me. I have read a lot on Savella and you are not supposed to take it with Zoloft or many SSRI's because of the serotonin. I guess if you do it really can cause major side effects. I still have low bp, but my pulse has gone down. I think maybe I need to get off of my bp medicine. I still need to go in and talk to the dr. I just can't believe how much better I feel. Now, the weather is going to change on Wednesday and I will know if it takes care of the IBS. I was taking muscle relaxers before this med. They help too. Glad your's is working for you. Everyone needs to seek out the best solution for their pain. Take Care! Share this post Link to post Share on other sites