Pain Medicine

[James Marusek 5,244]

I came across an interesting article this morning that discussed pain medication, specifically pain medication and relief after surgery. Many pain medicines are opioid based and there is the risk of addiction. Currently the government is clamping down on the use of these medications. This article discusses an alternative approach to pain management using a engineered chemical formulation. From my perspective it is analogous to a time release formulation. This looks like a valid approach to pain management that could very well be over the horizon in a few years.

Pacira, a New Jersey-based company that specializes in putting drugs into liposomes did just that. In 2011 the FDA approved EXPAREL, Pacira's liposomal Marcaine formulation, for the treatment of postoperative pain (6). Marcaine itself is no slouch when it comes to long-lasting pain relief, but the controlled release properties of EXPAREL make quite a difference. EXPAREL was effective for up to three days, compared to 7 hours for Marcaine. How well does it work? According to Dr. Dinenstein, very well. In 2012 Dinenstein began using the product off-label by injecting it directly into the wound while closing. About 95% of his patients had their pain controlled well enough that they didn't need any pain medications.

https://www.acsh.org/news/2017/10/20/surviving-post-op-pain-without-opioids-thanks-chemistry-11982

[Amburmist 55]

I came across an interesting article this morning that discussed pain medication, specifically pain medication and relief after surgery. Many pain medicines are opioid based and there is the risk of addiction. Currently the government is clamping down on the use of these medications. This article discusses an alternative approach to pain management using a engineered chemical formulation. From my perspective it is analogous to a time release formulation. This looks like a valid approach to pain management that could very well be over the horizon in a few years.
Pacira, a New Jersey-based company that specializes in putting drugs into liposomes did just that. In 2011 the FDA approved EXPAREL, Pacira's liposomal Marcaine formulation, for the treatment of postoperative pain (6). Marcaine itself is no slouch when it comes to long-lasting pain relief, but the controlled release properties of EXPAREL make quite a difference. EXPAREL was effective for up to three days, compared to 7 hours for Marcaine. How well does it work? According to Dr. Dinenstein, very well. In 2012 Dinenstein began using the product off-label by injecting it directly into the wound while closing. About 95% of his patients had their pain controlled well enough that they didn't need any pain medications.
https://www.acsh.org/news/2017/10/20/surviving-post-op-pain-without-opioids-thanks-chemistry-11982

Sounds promising. Its gotta stay as an injection, though, because its time or extended release and as a pill, wouldnt work for us bypassers. As an injection upon closing of the wounds or at the end of surgery while still under anesthesia, it sounds great!

[dcole007 21]

Sounds promising. Its gotta stay as an injection, though, because its time or extended release and as a pill, wouldnt work for us bypassers. As an injection upon closing of the wounds or at the end of surgery while still under anesthesia, it sounds great!

Extended release pills don't work after a gastric sleeve??


Best wishes!

Dotty Cole

[Amburmist 55]

Extended release pills don't work after a gastric sleeve??


Best wishes!

Dotty Cole

I dont know about sleevers but definitely not for bypassers.

[dcole007 21]

I dont know about sleevers but definitely not for bypassers.

Ok thanks. I was wondering because I take an extended release pain medication for my back and neck. It words so well and without side effects.


Best wishes!

Dotty Cole