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Medication Absorption Question Post RNY



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Hi guys. Can you help me brainstorm "hack" this please? I know when we have RNY our "tummys" are MUCH smaller and we also have shorter duodenums.

I'm taking an anti-cancer drug that is highly dissolvable/highly permeable (BCS Class 1) and is very quickly absorbed in the tummy and intestines, but it is a fat soluble drug rather than a Water absorbable drug. I know it isn't dependent on the pH environment for absorption.

So my goal would be to get my drug to "hang out" in my stomach as long as possible. So to me, that would mean, I should probably take it with dense Protein, once I've healed to the point of being able to eat dense protein. But in the short term when I'm able to eat things like yogurt, ricotta, and cottage cheese, what do you think is the one food that I could "take a bite of" to get the pill swallowed that will stay in my pouch the longest amount of time (anti-slider food)?

The drug I'm trying to max out on tummy time is letrozole (Femara) and is a tiny orange pill that is not enteric coated nor extended release.

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