tfarr 270 Posted April 17, 2015 I've been taking effexor for about 6 years. Hen added lamictal about a year ago. Since my surgery ( December 2) my moods are way out of whack at times. Like, for about two weeks at a time. Depression, mood cycling, forget about coming off. I'm glad I'm still on them lol Everyone is different though. Share this post Link to post Share on other sites