Wish They Would Come Out With Something New Besides Sleeve.

[betterthanbefore 19]

The balloon? Wow..that sounds very interesting.

[Capt Derel 287]

Also' date=' I've heard they are working on a pill to try and block ghrelin somehow. That's something I'd definitely be interested in. However, that'd do nothing for emotional eating and binging.[/quote']

Bodybuilders use a research chemical called Hexarelin and heres the info.

Hexarelin

Hexarelin belongs to a class of growth hormone secretagogues specifically known and referred to as Ghrelin mimetics or GHRPs. As opposed to GHRHs (growth hormone releasing hormones such as Sermorelin, Modified GRF 1-29, and CJC-1295), which are a separate class of growth hormone secretagogues, Ghrelin mimetics primarily increase growth hormone release in the somatotrophs within the pituitary. GHRHs, on the other hand, slighty increase somatotroph output while concurrently causing more somatrophs overall to release growth hormone.

Ghrelin mimetics have been demonstrated in clinical environments to release more growth hormone than GHRHs in comparison studies. [2] Ghrelin mimetics are less susceptible to environmental, hormonal, and physiological factors that inhibit GHRH-induced GH release, such as somatostatin, fatty acids circulating in plasma, and timing of the natural rhythmic growth hormone pulse in the human body. [1]

The most-studied Ghrelin mimetic peptides are GHRP-2, GHRP-6, hexarelin, and ipamorelin. Of these, ipamorelin is the least potent GH releasing compound but the compound that also has the least effect on cortisol and prolactin release. GHRP-6 is more potent with slightly more cortisol and prolactin release; GHRP-2 is more potent still; and hexarelin is the most potent of the four, with the most release of cortisol and prolactin as well. [3]

Each of the Ghrelin mimetics has unique properties largely unrelated, in most cases, to effecting the release of growth hormone from the pituitary. Hexarelin "reduces injury of cerebral cortex and hippocampus after brain hypoxia-ischemia in neonatal rats" according to one study; this effect may possibly be achieved with ghrelin, as well. [4] The ghrelin mimetics (GHRPs) are believed, as a whole, to potentially exert an antioxidant benefit on the testis by action involving the GHS-R type 1a present in Sertoli and Leydig cells; it may have antioxidant and anti-inflammatory effect through reduction of lipid peroxidation as well as increasing the activity of the body's three main antioxidant systems (superoxidate dismutase, glutathione peroxidase, and catalase), and may additionally protect spermatozoa from free radicals. [5]

Hahahaha. Whooa. Damn I have some indepth friends.

[Wheetsin 714]

That actually makes sense to me.

[Capt Derel 287]

Lmfao. Really. Simply they use it to mimic ghrelins growth hormone releasing agents in the body. Ghrelin just didnt control hunger. I knew that preop but I also knew about this preop as well.

Docs dont tell you everything apparently

[Wheetsin 714]

Ghrelin has been pretty strongly linked to memory, learning and overall cognitive function. And Alzheimer's.

(I work in the field of human performance science - lots of psychology, lots of systems thinking, and lots of other things that roll up into "making people better at what they do"... I have easy access to the research on this one and have been following it but it's still not a "hot topic" worthy of much investigation by the pros.)

Hopefully the ghrelin we have left will be enough, or 50 years from now we're all gonna be skinny as hell, we just won't know who we are or how we got so skinny.

[CamarilloCA 41]

I took Phentermine (1 pill) for about seven months and lost 70 pounds effortlessly. I didn't crave food; I didn't want junk food; and I filled up very quickly. I was at my ideal weight for about five minutes. Once I stopped taking it, the weight slowly crept back on and then about 20 pounds more -- just like every diet I had ever done.

Dr. Oz was just talking about how they are now combining Phentermine with another drug for weight loss. Drugs are not a permanent solution. They are only a temporary one.

Hunger is everything. Hunger is what drives you to eat, and hunger dictates what you eat. Your brain tells your body that you are hungry and to eat, and it does this to get you back to the weight that you once were plus a little more to prepare for the next time you starve it. The brain is very efficient at getting you to put on weight. It is a survival mechanism that humans developed long ago.

pills, Fiber bars, strict diets can help you lose the weight, but keeping it off is an entirely different matter. WLS is the answer to keeping it off. I know of very few people that have lost a lot of weight and kept it off. Not even Oprah with her personal trainers, personal chefs, and unlimited resources could do it. I would love to see her get the sleeve since I know her weight distresses her so much.

After 20 years of diet after diet and losing the same pounds over and over again, I finally figured out that I couldn't make it permanent without WLS. I think most of us here have come to that same conclusion.

[paulsgirl1297 18]

Chia seeds will expand in your stomach and make u feel full according to the nutritionist I saw - she said to mix them in with food (nothing too wet) and once liquid hits them they will expand in your stomach making you feel full. Haven't tried it yet but a few people at the doctors office had and said they worked.

We talked about those at my last support group meeting ..I never knew they were edible

[beautifulnewme2012 164]

The thing is, I could have the sleeve and end up with Alzheimers in my 60's or later...or not get the surgery, and probably not make it to my 50's.....my Aunt died in her early 50's from heart disease brought on my obesity...and there isn't any clear studies that show greater risk of Alzheimers after this type of surgery that I know of. So I have to choose surgery....

[paulsgirl1297 18]

They do have a bar called the full bar......I tried it and it didn't work for me, I did manage to lose weight on the opti fast shakes during the liquid pre-op diet I lost 15 pounds in two weeks, however I did cheat twice and I know that if I had decided to do the shakes instead of surgery I would've cheated and not stuck to that plann

[azquilter92 82]

There an article recently in our local paper,had to do with one of our hospitals now doing bariatric surgeries. One of the lines in the opening paragraph said" because no one can diet forever".which when you think about it is so very true,thats why alot of plans dont work.

[azquilter92 82]

There was an article recently in our local paper,had to do with one of our hospitals now doing bariatric surgeries. One of the lines in the opening paragraph said" because no one can diet forever".which when you think about it is so very true,thats why alot of plans dont work.

[kraftwrk 9]

Why cant they just create a pill that expands in your tummy to make u feel full instead of the pill. Why can't someone come up with a true plan of meals to loose weight? So fustrated. Weight loss is so difficult.

reading this made me think of those infomercials back in the 80s/90s. they had a pill that, if you took it, it would expand in your stomach and make you feel full. well, they took it off the market when people were dying of choking to death because the pill would expand in their throats or just before the stomach.

[Jill279 65]

Said best by some already...losing weight is easy...keeping it off for life is hard.

Hence my decision for the surgery.

[xlr8ahead 40]

The balloon? Wow..that sounds very interesting.

Yes it does .but in europe it costs £5.500 for 6 months of it being in. I looked into it.an everyone put the weight back on.id rather have vsg for life .an pay £8.500.

[LDallas 108]

Arena Pharmeceuticals and Oryxigen? pharm are working on wt loss drugs. Arena's is closer to being approved. I've asked pcp for rx for phentermine or something!! But hbp prevents it. I will be P*SSED if they approve a magic pill the day after my surgery!! LOL