After reading this forum I asked my Primary Care Doctor about a prescription for Zelnorm. I was suffering from severe constipation - sometimes going 4 days w/out a bowel movement. I tried laxatives and stool softners, prunes, fibersure - nothing worked. The 1st day I took Zelnorm I had a bowel movement and I've had one everyday since. It is a big relief. I highly recommend it if you are suffering from constipation like I was.