I am on the same thing. My psychiatrist split the Wellbutrin into two doses. I take 200 - so 100 twice a day. Since the Cymbalta has to be opened up, studies show one may not be getting 100 percent of the dosage. I am now on 60 mg twice a day. I was having a terrible time because my psych meds were not right until this change was made. I’m not totally ok yet, but it’s only been a couple of weeks. I am feeling better every day though. The study I’m speaking of my psych doc found while I was in his office. If you remain on the same dosage, you’ll only get 60 percent of the prescribed Cymbalta dosage. Good luck!