Thanks so very much for this amazing and thorough response! I have Major Depressive Disorder and have finally found a balance in my medication. I don't want to go back into the grey cloud again, especially after surgery. I appreciate your advice and will get in touch with my psychiatrist before and after surgery. I'm maxed on Cymbalta which is my SSNRI of choice, its a sustained release so might be an issue in dosing. We shall see. Thanks again!