I take several medications. For pain, depression and blood pressure. I’m able to take them all orally. If you are able to take cymbalta i salute you! I wish I could! It just makes me nuts as does Lyrica. Not only did cymbalta make me nuts but it caused me to gain weight. I’ve settled in nicely to 40 Mgs of Paxil and clonazam daily to help me through. I had a deep post op depression. Physical changes I guess? Hydro and occasional midol for my fibromyalgia.