Uh oh. We never explored going off of anti-depressants. Im on 120 grams of Cymbalta, for Fibro, and my pain level from co-current arthritis is unbearable. But, this may be my problem. I've lost 40 lbs. but I need to lose 90 more lbs. and I'm stuck at the 2+ year mark. Not much exercise is going on, due to pain. I'm STUCK