Yes, I am active daily. An average week I walk about 15-20 miles outside on a track for exercise. I have been on Vyvanse for almost two months with a monitored diet (low carb, no caffeine, high protein based) and I have lost almost 21 lbs so far. And I still have high bp and it hasn't had any bad effect on it so far. I'm still on the starting dose. My insurance won't pay for the surgery so I can't speak for those who have had it and are now having problems. I am beginning to understand what I have been doing wrong for so many years. I lost 100 lbs two years ago with diet and hard work (exercise too) and then I became careless. I do not want to be 250 lbs again. Ever!