I've been using vitamin patches for 8 months and my blood work is the same as it was before: perfect. I use the PatchMD brand. You gotta use them on an area that doesn't have a lot of fat, like a shoulder blade or collar bone. I also sometimes put it on my ankle.
I use the B-vitamin patches from PatchMD and I love them. I don't use the multi-vitamin patches, but after my first set of labs, everything was in the normal range so I guess they work well and I personally have no issues with irritation, although I'm sure everyone will react differently to them.