I was on Estrogen for many years - 23 yrs! But I had a hysterectomy and they took my ovaries (what was I thinking??!). Anyway, I never had any problems at all. My doc told me to wean off a year ago, so now I'm going thru real menopause. Ick. I would stay on it indefinitely if my doc hadn't told me I should get off. For me, she said the side effects outweighed the benefits. btw, I'm 60 yrs old.