I was on depo before I got banded for about a year. I got off, but I hated my periods, so i've been back on for 2 series of shots and I gained 9lbs since i've been on it. I noticed after the first shot I wasn't loosing anymore weight either. So i'm waiting for this second shot to wear off...Hopefully I'll be able to concieve in about 6-9 months. I know It takes a while to get it out of your system, and start ovulating again. But i'm pretty sure u cant loose because of the depo, unless its time for a fill. Good Luck