Yeah I was pretty disgusted about the hair loss and I didn't notice much difference while taking 5,000 biotin. In the past before my surgery, I used Viviscal with great results and MSM but I couldn't afford Viviscal along with the other supplements I had to take and MSM is just terrible tasting (but works lol)! If you take it, the water should be warm so it dilutes the crystals and you want to mix it with lemon. With my taste buds changing and all, I just couldn't force myself to continue. Initially I was using MSM for knee pain but then I found out it was very good for the hair. Make sure you start off with a low dosage. I went to fast and it gave me headaches plus you have to drink lot of water too.