I have had aggressive RA since age 20....Im now 41....with some pretty bad joint deterioration ect....had surgery april 22 ....have lost 51lbs...more active than Ive been in years....walking daily....yoga and some weights....been off my meds (which were plenty) for 4 weeks without issue......still nervous but excited that maybe this is finally my ticket!!....havent done panels yet....but three months before surgery my factor was 347........yuck!!......