From what I have researched & what I was told when my gallbladder was removed by the time you wake from anesthesia the majority has left your system, it's not something that lingers. Once you are awake enough to hold the baby you can nurse, & there are also plenty of pain medications that are 100% safe to nurse on, percocet for one, so that's not really my concern (as per LLL & Kellymom.com) it's more sustaining my supply, by 12 months he wont be nursing full time like he is now.