Thanks so much for your replies. This helps me as I go forward facing this decision. My TKR was due to a motorcycle accident and I have gained a lot of weight since then. I was a little overweight before the accident but now I am almost 100 pounds overweight. I know I would feel so much better if I could get the extra weight off me and I think this is the way to accomplish that. I've went to the seminar last week and I have an appointment with the doctor on Friday so I guess that's when I will know exactly what path I will be taking and when it will start. It's good to hear how soon your joints/body start feeling better after losing some weight, glad to know you feel the effects almost right away!