I started on Depo and Prozac in Dec. 2017. At the time, I had lost 40lbs from my highest weight. Within a year, I had gained it all back. Its hard to say how much was from each, as they are both well known for weight gain. That being said, I had VSG in Sept. 2021, so nearing 4 months post-op and I've lost about 65lbs. About 20 of that was pre-op, 45 post-op. I figure that's pretty average, given my starting BMI, age, etc. I'm now 10lbs lower than I was before I started the meds, and at my lowest ever adult weight and the loss seems to be holding pretty steady week over week.