I also was ER/PR/HER2, Nausea is quite controllable , and appetite not affected to much. The first three round of chemo are processed though your bladder so if you thinking you’ve been drinking a lot of water now, get ready. The last three rounds are the nasty ones, and the drugs wipe out your sense of taste. It comes back quickly when you’re done, though. That makes it really hard to eat because sun much food , even stuff you like, will taste like cardboard or sawdust. You’ll have to get creative with proteins . Don’t forget to get a new toothbrush every three weeks so you don’t get mouth cankers, which makes it hard to eat . No spread is WONDERFUL , I had it in three lymph nodes, and I’m fine ten years later. Herceptin , for HER2 is a miracle drug. If you’re getting radiation after chemo you will unlikely notice it affects you at all. Every day after chemo you feel so much better you’d have to get hit by a truck to get worse. You’re working on the two most amazing journeys ever, at the same time. So very brave and strong, and don’t forget that you are , even when you feel like crap. From here, the only way out is UP. Sending hugs. We’re all sisters in this. Pauline